Treatment of generalized pustular psoriasis-Clinical trials using different therapeutic modalities
Treatment of various types of pustular psoriasis, using dressings wet with Burow's solution alone, resulted in the clearing of pustules in 67 of 115 severe attacks in 26 mates and 21 females. The average number of days until spontaneous clearing was between 20 and 42; approximately one third of these attacks cleared within 20 days. Antichcmotactic medications such as tetracycline, dapsone and colchicinc cleared one third of the remaining non-spontaneously remitting attacks. The medications were ineffective in cases of chronic pustular eruption of the palms and soles for which a topical corticosteroid, with occlusion, was found to be useful. PUV A gave a favourable result in about half of cases of chronic drug-resistant pustular eruption of the trunk. Methotrexate CMTX) with or without non-steroidal anti-inflammatory agents could control cases of arthritis. Etretinate was efficient in treating two recalcitrant attacks; subsidence of the pustules occurred in I week. In conclusion, pustular psoriasis is a self-limited disease in cases of annular, exanthematous and impetigo herpetiformis, and in some cases of the von Zumbusch types. However, it may be a chronic, recurrent, progressive, intractable (especially the Hallopcau type), or rarely, even fatal disease. Methotrexate is not the drug of first choice for treating generalized pustular psoriasis.
ปีที่ตีพิมพ์ : 2528 ปีที่ : 110 ฉบับที่ : 1 หน้าที่ : 552-561 ประเภท: research
วารสาร : Clin Exp Dermatol
Keyword : psoriasis, 1985