To the Editor: Periorbital wrinkles are a routine finding in the aging face.1 Treatment of wrinkles has traditionally been by invasive means with significant recovery time. Nonablative energy devices that reduce periorbital wrinkles without prolonged post-treatment healing have been less studied.2,3 This study assessed and compared the effectiveness of fractional 1550-nm laser and focused ultrasound for the treatment of periorbital wrinkles.