A Comparative Split-Face Study Using Different Mild Purpuric and Subpurpuric Fluence Level of 595-nm Pulsed-Dye Laser for Treatment of Moderate to Severe Acne Vulgaris.
Various forms of laser therapy including the pulsed-dye laser (PDL) have been reported to reduce acnelesion counts.
OBJECTIVE: In this study, the benefits and complications when using a 595-nm PDL for the treatment of acne vulgariswere evaluated when comparing a subpurpuric (low) fluence level with a purpuric (high) fluence level.
MATERIALS AND METHODS: This study was a prospective, single-blinded split-face clinical trial. Inclusion criteria included subjects with moderate to severe facial acne. All participants were treated with PDL, with each half of the face receiving either high or low fluence at 3-week intervals for a total of 4 treatments. Standardized facial photographs were obtained and blindly evaluated.
RESULTS: Sixty-two subjects were enrolled with a mean age of 22.3 years. Fifty-five patients completed the study. The results showed a significant decrease in lesion counts compared with baseline after all treatments. However, the studydid not demonstrate a statistically significant difference between the fluence parameters. The only treatment-related adverse event was temporary hyperpigmentation.
CONCLUSION: This study demonstrates that PDL is effective in reducing acne lesions using purpuric and subpurpuricfluences. However, there was no statistically significant difference in acne lesion count between the higher and lower fluences.
ปีที่ตีพิมพ์ : 2559 ปีที่ : 42 ฉบับที่ : 3 หน้าที่ : 403-409 ประเภท: research
วารสาร : Dermatol Surg
Keyword : 595-nm Pulsed-Dye Laser, Acne Vulgaris, 2016